Can Noninvasive Tests Substitute Endoscopy for Diagnosis of Colonic Diseases?

Background and Aims: Fecal calprotectin was approved as a non-invasive screening tool for organic colonic diseases. The aim of this study to evaluate fecal inflammatory indices markers diagnosing differentiating bowel diseases (IBD) colorectal cancer (CRC) in comparison irritable syndrome (IBS) cohort Egyptian patients.
 Methods: In cross-sectional study, calprotectin, neutrophil lymphocyte ratio (NLR), platelet (PLR) systemic index (SII) were assessed 40 IBD patients, CRC 20 IBS Results: significantly higher groups compared control group (P= 0.018 0.022 respectively), with no significant difference between groups. PLR, NLR SII showed differences the 3 studied 0.469, 0.101 0.84 respectively). At cut-off value 113, had ability differentiate patients from 75% sensitivity 60% specificity, while 116, 67.5% 65% specificity.
 Conclusion: Inflammatory tested our (PLR, NLR, SII) role differentiation IBD, CRC, IBS. should be used caution primary step it cannot CRC. It has only moderate Unfortunately, neither nor can substitute endoscopy or diagnosis